Cell and gene therapies are generating excitement for their potential to treat diseases more precisely, but are expectations for these therapies realistic? Today, efforts are underway by multiple entities to create patient and provider educational resources that aim to illuminate how these therapies work. Are these materials answering the right questions? How well do our heterogeneous patient communities understand the common misconceptions about cell and gene therapies? Are we taking the right steps to ensure that the hopes for cell and gene therapies remain consistent with reality?