The World Health Organization predicts that 30.2 million people worldwide will be diagnosed with cancer in 2040. In response to this challenge, the cancer-care landscape is rapidly evolving. Ground-breaking innovations that have recently emerged across the cancer-care ecosystem include blood-based tests that can detect multiple cancers simultaneously, at-home screenings and treatment, customized vaccines to deliver targeted treatments, and imaging technologies less harmful than their predecessors. Panelists hypothesized what it may be like to have cancer in 2040 and discussed how we might reinvent the future of cancer care, devising novel approaches to prevention, screening, and treatment.