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Breakthroughs in biomedicine, climate science, and space exploration are reshaping our understanding of life on Earth and beyond. This panel brings together leaders from major science funding organizations to explore how large-scale philanthropy and investment can accelerate discovery across disciplines, from the molecular mechanisms of disease to climate systems and the cosmos. Panelists will discuss how funders can take bold risks, support interdisciplinary collaboration, build durable scientific infrastructure, and translate discovery into real-world impact. The session will also explore how coordinated funding strategies can unlock faster, more equitable, and more transformative scientific progress.