Michael Milken will deliver a rare keynote address—only his third in Global Conference history—sharing his reflections on the state of the world and the role of the Institute in addressing today's challenges. This year's speech will build on themes from his keynote in 2000, "The Promise," which anticipated transformative shifts driven by demographics, technology, and public health, and his 2017 speech "Building Meaningful Lives," which explored the profound human implications of technological displacement driven by advances in artificial intelligence and robotics. Milken will now examine the American Dream as a global aspiration, emphasizing values of equal opportunity, personal and economic freedom, broad access to education and capital, financial literacy, and a deep commitment to medical research and public health. At a time of global uncertainty, Milken will reaffirm the urgency of advancing these ideals as pathways to global prosperity.