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Health equity is foundational to economic growth and social stability. Achieving it requires collaboration between sectors to build systems that serve everyone across geographic and socioeconomic boundaries. Real progress can be made when investors in health infrastructure—and those on the ground—work with communities to address their own health needs. This panel brings together leaders from across the biomedical and health ecosystem who are building the necessary partnerships and represent the full spectrum of what it takes to achieve health equity, build resilient systems, and ensure that investments reach the communities that need them most.