There is a growing body of evidence underscoring the importance of meaningful relationships and social connections to maintain physical and mental health. Social connectedness is associated with a 50 percent reduced risk of early death; conversely, loneliness and social isolation increase the risk of heart disease, dementia, and stroke. Social prescribing offers a new avenue to treat social connectedness as a critical health issue, enabling physicians to address social needs alongside other determinants of health such as housing and food. This panel will examine the relationship between health and social well-being, highlight promising models, and explore approaches to scale social prescribing.