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The geopolitical landscape is undergoing its most significant transformation in decades, as shifting power dynamics, evolving alliances, and the reassertion of national interests reshape the frameworks underlying trade, security, and multilateral cooperation. This conversation brings together architects of foreign policy, stewards of global capital, and leading strategic voices to examine how these tectonic shifts are forcing fundamental recalibration across sectors and borders—from the fragmentation of globalization and regionalization of supply chains, to the intersection of commerce and statecraft, where business decisions carry geopolitical weight, and policy decisions have immediate market implications.