While health-care spending has increased, gaps in health-care outcomes and access have widened. The US spends $4.3 trillion annually on health, yet we are seeing a troubling decline in life expectancy. In addition, rates of maternal mortality are increasing, rates of chronic diseases are increasing, access to innovation is uneven, and social systems are falling behind. This trend of worsening health outcomes has been noted globally as well. What steps are being taken to ensure that scientific advances and innovations are translating to improvements in health and well-being? Leaders in this session will speak about the opportunities ahead to close the gaps in health and health care and lead to better health for more people.