Globalization is in a period of reconfiguration. The last several decades saw the deepening interconnectedness of value chains, trade flows, financial markets, digitalization of systems, and migration of labor and skills. More recent history, however, has recorded disruptions to the flow of goods, products, and services across borders, together with increased protectionist measures. As globalization transforms into its next iteration, how might institutions adapt their operational models and organizational systems to maintain cross-border innovation and economic efficiencies? How can technology and digitalization help address new macro-challenges and unlock opportunities for more segments? How can leaders ensure that this next iteration of globalization is more sustainable and reduces environmental impact?