Amid political turmoil and a slow economic recovery from COVID-19, Latin America has emerged as one of the hottest markets for entrepreneurs committed to redefining consumer behaviors while addressing significant social issues. Powered by large domestic markets and access to capital, São Paulo and Mexico City are leading the list, and other cities—such as Santiago, Buenos Aires, and Medellin—are catching up. Google´s recent investment to boost Latin America´s digital infrastructure signals the region´s potential as a global innovation and entrepreneurial hub. How can Latin America take full advantage of the opportunities offered by this technological explosion while ensuring long-lasting prosperity?