The past two years have been marked by moments that define a generation—the COVID-19 pandemic, supply chain breakdowns, a shift in American political power, unprecedented social movements, and more have all fundamentally changed how leaders lead. As the next decade unfurls and we look ahead to the uncertainty it may bring, how can C-suite members provide steadying and calm guidance for their companies? This panel featuring leaders from the health-care sector will seek answers to the question: How do you lead through the unknown?