Although the rapid development of COVID-19 vaccines has been an extraordinary success, the international distribution of, and access to, vaccines has been uneven at best. Many countries do not yet have sufficient quantities of the vaccines, raising many important scientific, policy, and moral questions. How vaccines are distributed globally will not only impact the long-term duration and subsequent waves of this virus, but will also inform the pace at which the world economy recovers from the COVID-induced downturn. This panel will discuss some of the challenges inherent in coordinating the global response, as well as the innovative strategies employed to ensure that vaccine distribution is not only equitable, but also contributes positively to both global recovery and local resiliency.