We are confronting a public health crisis in infectious disease, which highlights the longstanding public health crisis in chronic disease. How are leaders in government and industry tackling the challenges of chronic disease in the current COVID-19 pandemic? The patient perspective on living with chronic disease during COVID-19 offers insights into the effect of this added burden on chronic conditions. Business leaders and policymakers recognize the urgency of prioritizing management of chronic disease to prevent severe illness from COVID and future pandemics, and define the actions needed from policymakers, industry, and investors.