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Amy P. Abernethy, MD PhD is an internationally-known oncologist, health data expert and digital health leader. Her >500 publications span real-world data & evidence, clinical trials, patient reported outcomes, clinical informatics, health policy and patient-centered care. Most recently, Dr. Abernethy was Principal Deputy Commissioner and Acting Chief Information Officer of the US Food & Drug Administration, serving from February 2019 to April 2021. Dr. Abernethy initiated multiple critical efforts during her tenure including FDA's technology and data modernization action plans and FDA's efforts to leverage real-world data & evidence to address critical questions during the COVID-19 pandemic. Dr. Abernethy was Chief Medical Officer and Chief Scientific Officer at Flatiron Health from July 2014 to January 2019. Before joining Flatiron, Dr. Abernethy was Professor of Medicine at Duke University School of Medicine, and directed the Center for Learning Health Care in the Duke Clinical Research Institute and Duke Cancer Care Research Program in the Duke Cancer Institute. For more than 20 years, she has pioneered the development of technology platforms to spur novel advancements in clinical care, including the development of systems by which linked clinical data can support tracking cancer care, drug development, personalized medicine and scientific discovery.