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Recognizing that many of the most transformative biomedical breakthroughs, from gene editing to mRNA vaccines, have emerged from high-risk, long-horizon research, this roundtable affirms the unique and indispensable role of philanthropic organizations in advancing bold bets in biomedical science, catalyzing paradigm-shifting discovery in areas like disease biology, therapeutics, and diagnostics at a time when traditional funding mechanisms often favor incremental progress and shorter timelines. This roundtable will bring together leaders from biomedical research institutes and private foundations to explore how bold, long-term investments can unlock breakthrough discoveries in human health, drive systems change across the health ecosystem and redefine the future of medicine.