The global trading system faces grave challenges in the forms of mounting protectionism and nationalism, both of which stem from rising geopolitical tensions, growing macroeconomic imbalances, and shifting economic paradigms. Economic security, de-risking, and supply chain resilience are displacing liberalization at the center of the negotiating agenda—a trend the IMF warns could reduce global economic output by as much as 7 percent and undermine efforts to combat other challenges such as climate change and sovereign debt crises. This session will take stock of the ongoing transformations to the world economy and examine opportunities to reimagine economic integration during an age of disruption.