As science faces increasing challenges—from funding uncertainties to geopolitical pressures—collaboration between academic institutions and philanthropists has never been more crucial. This roundtable will bring together university leaders, researchers, and private funders to explore sustainable funding models, ethical considerations, and innovative partnership strategies that will ensure that scientific discovery thrives in the decades ahead. This interactive discussion will provide a platform for thought leaders to share insights, identify challenges, and develop solutions that reinforce the resilience and independence of scientific research.