Science has driven innovation for centuries. Serendipity contributed to many breakthroughs in the past. However, science has demonstrated that focused research initiatives with ambitious goals can solve some of society’s biggest questions while making new discoveries along the way. From the Human Genome Project mapping humankind’s genetic make-up, to the Apollo Program shooting for the moon and stars, philanthropy, government, and the private sector have much to learn from ambitious, collaborative initiatives to continue engineering breakthroughs in modern science. Panelists will glance back at scientific landmarks and look ahead to some of the goals waiting to be discovered around the scientific corner.