Children and youths, affected deeply by the COVID-19 crisis, are reckoning with a different kind of epidemic. Pervasive depression and anxiety, rising rates of substance misuse, increasing isolation and loneliness—all are contributors to the sad status quo. Society must find ways to address the needs of younger generations, both outside and inside the classroom, to ensure a healthy and thriving future. Join specialists and advocates to chart a new path with solutions that will prove durable over time.