Since March 2020, routines have been disrupted and economies have contracted. Millions of people are grieving for lost loved ones and lost ways of life. The crisis, however, offers an unprecedented opportunity for philanthropists to lead a global reset of systems that have long been in disarray. Funders from major philanthropic sectors—biomedical research, mental health and education, mental health and wellness, and the environment—will propose and analyze steps philanthropists and foundations can take to "give smarter" in the age of COVID-19, with the goal of building back a better world for all.