The rapid progress of mental health and brain disorder-focused research has changed how we think and speak about mental health and the brain. A driver to this evolution is the influx of philanthropic capital to support brain-focused research, which is essential to millions of people living with mental health challenges and brain-based disorders. Although advances in brain-focused research and technology have begun to upend traditional clinical models, how do we continue to drive progress using philanthropy as a lever for change? This private session will feature philanthropic leaders and how their philanthropic mission relates to our understanding of mental health, the brain, and the path forward.