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Advances in AI, genetics, and therapeutics are among the new generation of technologies creating opportunities to prevent, manage, and even cure diseases once considered intractable. Where are innovators placing their biggest bets, and which advances have the greatest potential to transform human health? Realizing that potential, however, will require more than scientific and technological breakthroughs alone. As the pace of innovation accelerates, how can we ensure innovation translates into better health for more people?