The population of trusted intermediaries for health information, research engagement, and services is shifting. Established stakeholders are learning to collaborate in new ways and with new partners to reach communities and build relationships. Trust in health care and research institutions is critical to engaging people in improving their own health and our collective well-being, as well as to conduct research that generates robust evidence and moves toward better health for all. While people often say they trust their own doctors, the roots of mistrust in the larger health-care system run deep and often require hard work to eradicate. How is the need to build trust disrupting the way health care and research occur in and with communities? And who are the surprising new partners? This panel reviews the opportunities and challenges these shifts present.