AI tools are at the frontier of scientific innovation with significant potential to accelerate biomedical discovery. Research across academia and big tech, along with biotech/pharma investments and philanthropic capital, continue to push the limits of these technologies. How can we ensure the potential benefits to society, including improvements in health and health care, are realized responsibly and equitably? This session will highlight trailblazing ideas and initiatives that are leveraging the power of AI, combined with big data and science, with the ultimate goal of improving the health and well-being of people globally.