Approaches to chronic disease prevention in the United States are often siloed, even though six in 10 Americans live with a chronic condition and four in 10 with at least two. Many of the risk factors for cardiovascular disease, diabetes, and hypertension increase the likelihood of developing Alzheimer’s disease and related dementias, now sixth among causes of death in the US. The CDC and Alzheimer’s Association’s Healthy Brain Initiative Road Map for 2023-2027 includes the objective of integrating dementia prevention with other chronic disease efforts. As lifespans increase and the population ages, reducing the societal and economic burden of chronic comorbidities becomes increasingly important, requiring cross-sector collaboration, innovation, and investment. Examining the intersections of cognitive and physical diseases and their risk factors, panelists will review innovative approaches to address structural determinants of health, integrate mind-body interventions, and promote whole-person health over the life course.