Over half (six in ten) Americans live with a chronic disease, and four in ten live with at least two. Obesity, diabetes, hypertension, and hypercholesterolemia are common in US. Not only are these conditions associated with increased risk of poor outcomes with COVID-19 infection, they also—alone or in combination—can result in devasting complications as they progress. These include chronic kidney disease and dementia, leading to lower quality of life, and driving the 4.1 trillion annual health-care costs. To tackle these complex health issues, a collection of diverse stakeholders, in conjunction with a whole-of-society approach are needed to create a vision of change, assume leadership, identify supporting roles, and outline the partnerships and collaborations needed to move forward with intention and urgency. This private session brings together a diverse group of participants—including policymakers, non-profit and private sector leaders, as well as nontraditional health sector representatives—for an informative, candid discussion about the policy priorities and investments needed to collectively address the burgeoning chronic disease challenges.