As a result of the COVID-19 pandemic, systemic health-care inequities persist along with public skepticism and mistrust in the system. Medical researchers and providers, policy makers, and business leaders can highlight the importance of ROI by establishing ways to draw on the expertise of nontraditional community stakeholders. A focus on ROI—a "win-win" for both patients and biomedical industry—can help build trust among deeply skeptical groups. What is industry's role in addressing health equity while building value based on the expertise of underrepresented groups? Panelists propose actionable solutions and best practices for integrating ROI, aligning incentives, and widening access to vital therapies while enlisting patients and communities in building an equitable biomedical research ecosystem. A further focus is the role of business and finance in prioritizing community investment and value to achieve health equity.