Remarkable innovation in the last several years has addressed many health-care needs around the world. Technology platforms and scientific breakthroughs are enabling improvements in the development of medical products, public health measures, and the delivery of health systems and interventions. However, far too many people are still left behind. What’s the most efficient way to break down barriers and accelerate biomedical research? How can we strengthen public health? What are the most innovative solutions proposed to advance healthy longevity and create a healthier, more equitable future across society? Leaders in health care will discuss these topics, challenging the status quo and predicting likely progress for the coming decades.