They’re not just for anti-inflammatories and bandages anymore. Retail pharmacies are entering the clinical research space in a follow-up to their successes with efficacy research on vaccines for COVID-19. These businesses have a dramatic reach and access to patients who often live too far for easy access to traditional commercial and academic sites, and thus are systematically under-represented in clinical research. Retail pharmacies are also in locations that patients are used to. With these advantages, retail pharmacies are poised to change the nature of a system that has often struggled with changing models in the past. What are the likely long-term effects of this shift on health care and clinical studies?