The challenges and opportunities facing US foreign policymakers displays a degree of continuity across successive administrations. The 'extreme competition' that characterizes relations with China and ongoing tensions with Russia present acute difficulties to both policymakers and investors alike. Alternatively, the Middle East finds itself entering an era of greater regional cooperation, not only on matters of security but also around constrained resources like energy and water, while Africa and Latin America remain regions of tremendous possibilities. How the US navigates these evolving complexities in global affairs, balancing the pursuit of security with shared economic prosperity and democratic values, is at the center of this discussion.