Rapid advances in science and technology are creating unparalleled opportunities to strengthen and improve the US health-care system. The US Department of Health and Human Services (HHS) plays a central role in protecting the health of all Americans and in providing essential health services, particularly to the most vulnerable. In this discussion, Secretary Becerra and former Secretary Azar will discuss strategies for government to address inequities in the health-care system, ensure access to affordable care, and strengthen our nation’s ability to respond to future public health crises.