Global aging has profound impacts on families, societies, and economies. Despite advances in biomedical research and improved living conditions around the world, age remains the biggest risk factor for diseases like cancer, diabetes, and Alzheimer’s. A multipronged ‘whole life’ approach can address the different but interacting biological and environmental drivers of health and disease. Geroscience targets common internal aging pathways to prevent or reverse these diseases. However, external factors like air pollution, green spaces, diet, and work spaces also interact and greatly influence our aging processes. Longevity Cities aim to optimize the external environment, reducing cumulative negative environmental exposures to improve later-life outcomes. This panel will focus on initiatives in the Middle East and Africa to establish “Longevity Cities” and enhance overall health.