Transformational philanthropy has the potential to disrupt fields by challenging the status quo and deploying mechanisms for change. With an appetite for risk and employing innovative financing mechanisms such as venture philanthropy and impact investing, these funders embrace transparency, have a hyper focus on data, and collaborate with other stakeholders to shape their disruptive philanthropy. Whether tech-focused mechanisms or monumental shifts in mindsets and paradigms, this disruption- and systems-change approach to philanthropy can catalyze capital and build momentum and networks to make even greater impact.