As a significant driver of change, philanthropy has innovated on ways to overcome structural obstacles, accelerate progress against disease, and combat global challenges—from climate to inequality. In recent years, the philanthropic landscape has shifted dramatically, with individual funders and foundations increasingly leveraging a variety of asset classes, inclusive of grants, impact investments, traditional financial investments, and prize competitions and programs to catalyze systems change across the world. This private discussion will focus on harnessing the power of philanthropic capital to create transformative change.