As new technologies are fundamentally restructuring the workplace and sustainability becoming of central importance amid an increased demand for more equitable access to health and income, city leaders across America must rethink their approach to economic growth. Evidence-based scalable programs, innovative new policies, and effective public-private partnerships are needed to increase access to opportunities across education, health, finance, and entrepreneurship. In this session, we will hear from a new generation of pioneering young mayors about how they are advancing economic and social mobility in their regions to drive prosperity and help more people create more meaningful lives.