Opportunity Zones (OZs), created as part of the 2017 Tax Cuts and Jobs Act, aim to use tax incentives to encourage investment in low- to moderate-income communities. While these investments can range from real estate to operating companies, it's crucial to ensure that they are aligned with the original intent of improving the lives of local residents. Poor health outcomes among residents in OZs are tied to economic disparities in these areas. Research conducted by Navigant in 2019 shows that hospitals in rural areas are closing at a rapid rate, with 95 rural hospitals in 26 states having closed since 2010. Moreover, studies show that low-income neighborhoods offer greater access to food sources that promote unhealthy eating, contributing to a myriad of health issues—obesity, chronic heart disease, and cancer. The potential to leverage private-sector dollars to address public-health issues offers a unique opportunity to address key societal issues through commercially viable means. Can the OZ initiative promote commercially viable investments with a health and wellness mission (for example, hospitals, medical research, or health-food grocery stores)? This private session will explore how industry experts, investors, policymakers, and local and state governments can work together to explore how OZs can be leveraged to improve health outcomes.