The challenges in developing new antibiotics have left us vulnerable to growing antimicrobial resistance. The lack of investment and slow movement in the development pipeline mean no replacements for ineffective antibiotics as drug resistance spreads. Without new antibiotics and treatments, an estimated 10 million people a year will die by 2050. What novel therapies and technologies can we utilize to bolster the human microbiome and combat antimicrobial resistance? And how can we effectively save the new antibiotics currently in development for future generations?