The world is just beginning to come to grips with the enormity and urgency of our global mental health crisis. In addition to the severe emotional cost to individuals and communities, an October 2018 report by the Lancet Commission on Global Mental Health warns that, left unchecked, the proliferation of anxiety, depression, violence, and trauma will cost the global economy $16 trillion by 2030. Like physical health, mental health requires awareness, vigilance, care, and management. However, many models used for assessing mental health issues are based on a Western point of view that may overlook important features of MENA cultures and experiences. Leading experts will discuss local and worldwide causes of mental health disorders, as well as the most effective treatments currently available.