As precision medicine and individualized treatments advance, oncology is leading the way. Precision oncology, using individual genetics and cancer biomarkers to point to the right treatment at the right time for a patient, is revolutionizing cancer care. And precision prevention can help individuals understand their risks of getting cancer and how to reduce their risks. New diagnostics and early screening protocols are reducing the number of people diagnosed at a later cancer stage, but challenges with stigma and access remain. How is precision oncology changing the paradigm for cancer prevention, screening, diagnosis, and treatment? What opportunities exist to overcome challenges to equitable access to screening and treatment? What new technologies will we see in the future and how will they lead to better outcomes?