The storied history of US-Mexico relations entered a new phase in 2020, with elections on both sides of the border, new leadership in the US, and the United States-Mexico-Canada Agreement (USMCA) coming into force, all amidst the pandemic and the pandemic-induced recession. COVID-19 exposed the risks associated with geographically dispersed supply chains, and each country's response to the pandemic impacted manufacturing and clouded investment outlooks. Despite this, the US-Mexico trade relationship is as strong as ever, with each country the primary trading partner of the other. While policy disagreements on immigration and security persist, the mutual commitment to shared prosperity presents significant cross-border opportunities for economic growth. Will the differences in policy outweigh issues of mutual interest in the coming years? How do cross-border corporations plan to navigate this relationship?