The stress and strain of the COVID-19 pandemic may lead to long-term health problems indirectly attributable to the virus. Trauma and toxic stress in childhood can actually change DNA, dramatically affecting the brain and other critical body systems. The cumulative effects of trauma and toxic stress may aggravate the risk for later health problems, such as heart disease, diabetes, and substance abuse disorders. The overall effect can contribute to and exacerbate disparities measurable in public health. Responses to the COVID-19 pandemic may be amplifying adverse childhood experiences, termed ACEs, with implications for public health far beyond the development of a vaccine. Panelists will review interventions that may help children and their care providers modify their responses to trauma and mitigate its effects.