Chronic under-investment and less-than-ideal global cooperation led to the failure of surveillance systems to provide timely warning of the threat posed by COVID-19. Public health officials consequently struggled to track the spread of the virus. As we contend with the long-term social and economic fallout of the pandemic, the importance of active, coordinated global early warning systems is painfully clear. The human toll has yet to be fully tallied; economic damage across industries may make it even worse. These outcomes raise questions about the potential role of private corporations and financial markets in a better coordinated effort. How do we envision an "always on," active, coordinated global system? What investments are needed to ensure the system is sustainable? What is the best way to gain commitments from governments, funders, financers, and communities to invest in such a system?