Las Vegas Strip, Pulse Nightclub, Virginia Tech, Sandy Hook, Robb Elementary School, mass shootings and their aftermath have continued to dominate headlines in the midst of multiple public health crises. In Washington DC alone, 2022 is on track to become the most violent year in nearly two decades. Gun violence has become a chronic public health crisis in the United States, costing more than 110 lives each day, and more than $280 billion each year. The shared trauma among victims, families, and communities continues to spread as shootings become more frequent. Policymakers, companies, and clinicians are compelled to act in a way that instigates both policy change and harm reduction. Chief executives at over 220 American companies co-signed a letter urging members of the US Senate to take "bold, urgent action" to pass legislation to reduce gun violence in the US. Following on an important discussion at the 2019 Future of Health Summit, this panel will examine what meaningful progress has been made to confront gun violence in the US, and how communities, companies, and organizations can mitigate this uniquely American public health crisis.