For the first time in decades—across race, socioeconomic status, gender, and community—Americans can expect shorter lifetimes. Socially impelled public health crises often drive adverse change. Gun violence, hunger, racism, suicide, and opioid abuse: All contribute to an increasingly unstable social and health environment. None of these issues are new or unknown, but progress towards long-term solutions is slowed by lack of social will and policymakers' inaction, among other barriers. Social movements are driven by advocates with well-known legacies. Panelists will explore what we can derive from cross-sector collaboration and lessons learned from the many social movements in public health. Can gun violence opponents learn from anti-tobacco campaigns? How have both been influenced by the AIDS crisis response? How have these movements grown and evolved over time? What common threads can we use for making a meaningful impact towards ending epidemic scourges in society?