Facing any number of seemingly intractable challenges in global health—from rare diseases to infectious outbreaks—philanthropists and multisector collaborators more than ever have a critical role to play. Bold action, big ideas, and significant investment are essential to solve these issues. Enter moonshots—an approach to tackling complex issues by supporting breakthrough innovations, technologies, research, and collaborations. Philanthropists and organizations who support the moonshot concept believe that audacious goals can be achieved when fearlessness, risk tolerance, an inclination toward the unconventional, and acceptance of failure contribute to the process. We’ll hear from ultra-high-net-worth individuals and multisector collaborators who deploy their significant resources and expertise in making big bets on individual causes to generate transformational impact.