The collective clinical research system needs to be thoroughly reconsidered: designed with end users in mind; built to earn trust in research aims and execution; able to maximize the likelihood of engaging the targets—people and communities—stakeholders need to reach. We need to disrupt the paradigm, taking a person-centered, data-driven approach to engage the broadest population of Americans in opportunities to take part in research. New players entering the research enterprise are bringing unique abilities to generate participant and community insights that can influence research objectives, design, and adoption; define, track, and improve participants’ journeys through the research process; measure and drive accountability for outcomes that matter to participants and communities as well as research stakeholders; and reframe research as an opportunity for inclusion rather than a requirement for diversity.