The world is reeling from the convergence of major crises including the climate emergency and the COVID-19 outbreak. Amid the tumult, philanthropists maintain a crucial role in mitigating the effects of disruptions. Thanks to their unique ability to deploy capital quickly and flexibly, philanthropists have mounted first responses to needs across the world. However, continued volatility has laid bare the concerted dynamism required to meet the urgent and complex challenges we face. How can medical and sustainability-centered philanthropy build a more transformative, resilient approach to both global health and climate issues? What would increase the impact of responses? And how can philanthropists partner with other change-makers to create a meaningful footprint?