Structural and demographic shifts are opening opportunities to innovate health-care systems. A growing consensus holds that health-care systems should emphasize patient-centric services and preventive care; improve affordability, quality, and access; and integrate digitization to improve the patient experience and empower patients with information, resources, and collaboration. Experts on this panel will review the trends that are driving urgency to build better health-care systems. They will assess approaches companies and providers might take to transition successfully to the next era of service delivery. Further points for debate include the investments needed to scale innovations and unlock the greater potential of digitization for patient-centric care models, and the role of the community and local jobs to support the transformation of care in a post-COVID world.