Global events have showcased our unprecedented ability to innovate rapidly in biomedical R&D when it is absolutely required. As we move forward, how can we sustain this momentum and tackle major long-standing challenges in health care? Experts will discuss a broad range of advances, including technologies that enable precision prevention, personalized medicine, and artificial intelligence, and delve into the strategies needed to leverage data, overcome barriers to care, and ensure that these innovations reach those who need them most.