With limited commercial incentives and high development costs, rare disease innovation often faces a persistent funding gap between early research and market-ready solutions. This closed-door session will convene philanthropic funders to examine how venture philanthropy can help close that gap—by de-risking early-stage science, supporting translational research, and building investable pipelines. Participants will have the opportunity to share experiences, candidly discuss challenges in rare disease investment, and brainstorm actionable strategies to accelerate the development of treatments and cures.